A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type II A muscle fibers, and possibly protection from exercise-induced muscle damage. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Nature Genetics volume 54, pages 1332–1344 ( 2022) Cite this articleĪlthough physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. He remains a director of his own media consulting company, Negus Media International.Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention He presented 6.30 with George Negus on Network Ten. He was awarded a Walkley Award for Outstanding Contribution to Journalism. He often reported from the frontline of dangerous conflicts and described himself as an “anti-war correspondent” who wanted people to understand the reasons behind why wars were senseless. Recognition of his unique skills led to him hosting a new ABC show, Foreign Correspondent, and Dateline on SBS. His very direct interviewing technique occasionally caused confrontation, famously with Margaret Thatcher, but also led to some interviewees giving more information than they had given in other interviews. Negus was known for making complex international and political issues accessible to a broad audience through his down-to-earth, colloquial presentation style. He was a pioneer of Australian TV journalism, first appearing on the ABC’s groundbreaking This Day Tonight and later on Sixty Minutes. George Edward Negus AM is an Australian journalist, author, television and radio presenter specialising in international affairs.
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